Buxton, Iain
Foundation Professor of Pharmacology
Positions
member of
clinical activities
selected publications
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academic article
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LC/MS/MS data analysis of the human uterine smooth muscle S-nitrosoproteome fingerprint in pregnancy, labor, and preterm labor.
Data in brief.
4:591-594.
2015
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Proteomic network analysis of human uterine smooth muscle in pregnancy, labor, and preterm labor.
Integrative molecular medicine.
2:261-269.
2015
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Integrin upregulation and localization to focal adhesion sites in pregnant human myometrium.
Reproductive sciences (Thousand Oaks, Calif.).
20:804-812.
2013
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TREK-1 currents in smooth muscle cells from pregnant human myometrium.
American journal of physiology. Cell physiology.
305:C632-C642.
2013
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The human uterine smooth muscle S-nitrosoproteome fingerprint in pregnancy, labor, and preterm labor.
American journal of physiology. Cell physiology.
305:C803-C816.
2013
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Uterine smooth muscle S-nitrosylproteome in pregnancy.
Molecular pharmacology.
81:143-153.
2012
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Variants of stretch-activated two-pore potassium channel TREK-1 associated with preterm labor in humans.
Biology of reproduction.
87:-.
2012
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A role for nucleotides in support of breast cancer angiogenesis: heterologous receptor signalling.
British journal of cancer.
104:1628-1640.
2011
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A role of stretch-activated potassium currents in the regulation of uterine smooth muscle contraction.
Acta pharmacologica Sinica.
32:758-764.
2011
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Extracellular NM23 Signaling in Breast Cancer: Incommodus Verum.
Cancers.
3:2844-2857.
2011
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Agonist-specific compartmentation of cGMP action in myometrium.
The Journal of pharmacology and experimental therapeutics.
335:256-263.
2010
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Expression of stretch-activated two-pore potassium channels in human myometrium in pregnancy and labor.
Public Library of Science One.
5:-.
2010
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Purinergic mechanisms in breast cancer support intravasation, extravasation and angiogenesis.
Cancer letters.
291:131-141.
2010
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Measurement of human breast tumor cell-secreted shNDPK-B in a murine breast cancer model suggests its role in metastatic progression.
Proceedings of the Western Pharmacology Society.
52:88-91.
2009
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Purinergic regulation of vascular endothelial growth factor signaling in angiogenesis.
British journal of cancer.
100:1465-1470.
2009
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Agonist-specific regulation of inositol phosphate metabolism in cardiac endothelial cells.
Proceedings of the Western Pharmacology Society.
51:23-26.
2008
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Cyclic GMP/protein kinase G phosphorylation of Smad3 blocks transforming growth factor-beta-induced nuclear Smad translocation: a key antifibrogenic mechanism of atrial natriuretic peptide.
Circulation research.
102:151-153.
2008
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Inhibition of Nm23H2 gene product (NDPK-B) by angiostatin, polyphenols and nucleoside analogs.
Proceedings of the Western Pharmacology Society.
51:30-34.
2008
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Nitric oxide stimulation of cGMP accumulation in myometrial cells from pregnant women is antagonized by oxytocin.
Proceedings of the Western Pharmacology Society.
51:78-82.
2008
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P2y receptor-mediated angiogenesis via vascular endothelial growth factor receptor 2 signaling.
Proceedings of the Western Pharmacology Society.
50:58-60.
2007
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Purinergic regulation of angiogenesis by human breast carcinoma-secreted nucleoside diphosphate kinase.
British journal of cancer.
97:1372-1380.
2007
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Validation of the CSI health station 6K blood pressure kiosk.
Proceedings of the Western Pharmacology Society.
50:181-183.
2007
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Cholesterol depletion enhances both spontaneous and agonist-evoked uterine smooth muscle contractions in a reversible manner.
Proceedings of the Western Pharmacology Society.
48:126-128.
2005
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Economic justification for a public school of pharmacy: lessons for Nevada.
Proceedings of the Western Pharmacology Society.
48:1-12.
2005
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Expression of stretch-activated potassium channels in human myometrium.
Proceedings of the Western Pharmacology Society.
48:44-48.
2005
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c-Abl is required for staurosporine-induced caspase activity.
Proceedings of the Western Pharmacology Society.
48:110-117.
2005
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Nucleotides in the blood stream.
Proceedings of the Western Pharmacology Society.
47:6-17.
2004
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Regulation of uterine function: a biochemical conundrum in the regulation of smooth muscle relaxation.
Molecular pharmacology.
65:1051-1059.
2004
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Caveolar compartmentation of caspase-3 in cardiac endothelial cells.
Cellular signalling.
15:489-496.
2003
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Changes in small conductance potassium channel expression in human myometrium during pregnancy measured by RT-PCR.
Proceedings of the Western Pharmacology Society.
46:74-77.
2003
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Dissociation of cGMP accumulation and relaxation in myometrial smooth muscle: effects of S-nitroso-N-acetylpenicillamine and 3-morpholinosyndonimine.
Cellular signalling.
15:763-772.
2003
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Vascular actions of the polyphenolic catechin gallate EGCG: endothelium-dependent contraction and relaxation.
Proceedings of the Western Pharmacology Society.
46:37-38.
2003
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What is it about the uterus anyway?
Proceedings of the Western Pharmacology Society.
46:1-8.
2003
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Calcium-activated potassium channel expression in human myometrium: effect of pregnancy.
Proceedings of the Western Pharmacology Society.
45:184-186.
2002
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Excitatory motor innervation in the canine rectoanal region: role of changing receptor populations.
British journal of pharmacology.
137:1321-1329.
2002
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Functional compartmentation of endothelial P2Y receptor signaling.
Circulation research.
91:292-299.
2002
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Isolation and characterization of large numbers of endothelial cells for studies of cell signaling.
Microvascular research.
64:302-315.
2002
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Nucleotide-mediated relaxation in guinea-pig aorta: selective inhibition by MRS2179.
British journal of pharmacology.
135:537-545.
2002
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Actions of S-nitroso N-acetyl penicillamine and 3-morpholinosydonimine may involve disparate signaling pathways in myometrial smooth muscle.
Proceedings of the Western Pharmacology Society.
44:53-56.
2001
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Caspase-3 is localized to endothelial caveolar domains.
Proceedings of the Western Pharmacology Society.
44:45-48.
2001
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Ellagic acid inhibits nucleoside diphosphate kinase-B activity.
Proceedings of the Western Pharmacology Society.
44:57-59.
2001
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Endothelium-dependent, MRS2179-independent actions of uridine 5'-triphosphate in guinea pig aorta.
Proceedings of the Western Pharmacology Society.
44:49-51.
2001
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Evidence supporting the Nucleotide Axis Hypothesis: ATP release and metabolism by coronary endothelium.
American journal of physiology. Heart and circulatory physiology.
281:H1657-H1666.
2001
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Hypertension as a complication of topical testosterone therapy.
The Annals of pharmacotherapy.
35:1205-1207.
2001
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NO-induced relaxation of labouring and non-labouring human myometrium is not mediated by cyclic GMP.
British journal of pharmacology.
134:206-214.
2001
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Secretion of a nucleoside diphosphate kinase (Nm23-H2) by cells from human breast, colon, pancreas and lung tumors.
Proceedings of the Western Pharmacology Society.
44:61-63.
2001
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Regulation of uterine contraction: mechanisms in preterm labor.
AACN clinical issues.
11:271-282.
2000
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Role of nucleotides and nucleosides in the regulation of cardiac blood flow.
AACN clinical issues.
11:241-251.
2000
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Measurement of phosphoinositols and phosphoinositides using radio high-performance liquid chromatography flow detection.
Methods in molecular biology (Clifton, N.J.).
105:47-63.
1998
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Nitric oxide regulation of monkey myometrial contractility.
British journal of pharmacology.
124:63-68.
1998
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Nitric oxide relaxes human myometrium by a cGMP-independent mechanism.
The American journal of physiology.
275:C1668-C1673.
1998
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Competition of adenine nucleotides for a 1,3-[3H]-dipropyl-8-cyclopentylxanthine binding site in rat vas deferens.
Clinical and experimental pharmacology & physiology.
24:492-497.
1997
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Cyclic GMP-independent effects of nitric oxide on guinea-pig uterine contractility.
British journal of pharmacology.
119:737-743.
1996
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Evidence for a discrete UTP receptor in cardiac endothelial cells.
British journal of pharmacology.
117:1572-1578.
1996
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HHMI Awards.
Science (New York, N.Y.).
271:-.
1996
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Detection of nitric oxide release from canine enteric neurons.
Journal of the autonomic nervous system.
56:61-68.
1995
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Inositolpolyphosphate binding sites and their likely role in calcium regulation in smooth muscle.
The international journal of biochemistry & cell biology.
27:1231-1248.
1995
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Cyclic GMP-independent relaxation and hyperpolarization with acetylcholine in guinea-pig coronary artery.
British journal of pharmacology.
111:1053-1060.
1994
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Neuropeptide Y potentiates norepinephrine-stimulated inositol phosphate production in the rat tail artery.
Life sciences.
55:103-109.
1994
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Purinergic axis in cardiac blood vessels. Agonist-mediated release of ATP from cardiac endothelial cells.
Circulation research.
74:401-407.
1994
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Adenosine-stimulated contraction in nonpregnant guinea pig myometrium does not involve cyclooxygenase.
The Journal of pharmacology and experimental therapeutics.
264:1033-1039.
1993
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Beta-adrenergic inhibition of electrical and mechanical activity in canine colon: role of cAMP.
The American journal of physiology.
264:G708-G717.
1993
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Inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate binding sites in smooth muscle.
British journal of pharmacology.
109:905-912.
1993
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NG-nitro L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists.
Circulation research.
72:387-395.
1993
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Protein kinase regulation of muscarinic receptor signalling in colonic smooth muscle.
British journal of pharmacology.
108:613-621.
1993
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[Ca2+]i-sensitive, IP3-independent Ca2+ influx in smooth muscle of rat vas deferens revealed by procaine.
British journal of pharmacology.
110:1353-1358.
1993
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Action of alpha 2A-adrenergic receptors in circular smooth muscle of canine proximal colon.
The American journal of physiology.
262:G517-G524.
1992
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Involvement of cyclic GMP in non-adrenergic, non-cholinergic inhibitory neurotransmission in dog proximal colon.
British journal of pharmacology.
107:1075-1082.
1992
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Negative-feedback regulation of excitation-contraction coupling in gastric smooth muscle.
The American journal of physiology.
263:C1160-C1171.
1992
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Phosphatidyl inositol-turnover provides negative-feedback for excitation-contraction coupling in gastric smooth muscle.
Japanese journal of pharmacology.
58 Suppl 2:-.
1992
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A1 adenosine receptor stimulation of IP1 degradation in myometrial smooth muscle.
Proceedings of the Western Pharmacology Society.
34:261-268.
1991
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Action of adenosine in estrogen-primed nonpregnant guinea pig myometrium: characterization of the smooth muscle receptor and coupling to phosphoinositide metabolism.
The Journal of pharmacology and experimental therapeutics.
258:429-437.
1991
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Adenosine A1-receptor coupling to phosphoinositide metabolism in pregnant guinea pig myometrium.
The American journal of physiology.
261:E665-E672.
1991
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Muscarinic receptors in canine colonic circular smooth muscle. I. Coexistence of M2 and M3 subtypes.
Molecular pharmacology.
40:943-951.
1991
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Muscarinic receptors in canine colonic circular smooth muscle. II. Signal transduction pathways.
Molecular pharmacology.
40:952-959.
1991
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Smooth muscle adenosine A1 receptors couple to disparate effectors by distinct G proteins in pregnant myometrium.
The American journal of physiology.
261:E141-E150.
1991
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ATP as a cotransmitter.
Annals of the New York Academy of Sciences.
603:300-310.
1990
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Does the inositol phosphate signalling system function in the heart? A comparison of inositol lipid turnover in cardiac and smooth muscle.
Proceedings of the Western Pharmacology Society.
33:111-115.
1990
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On the ability of endogenous adenosine to regulate purine nucleoside receptor binding of antagonists in smooth muscle membranes.
The Journal of pharmacology and experimental therapeutics.
255:886-892.
1990
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Dissociation between adenosine receptors and adenylate cyclase in the smooth muscle of guinea pig myometrium.
Cellular signalling.
1:357-365.
1989
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Factors involved in the generation of tension during contraction to high potassium in the rat vas deferens.
Cellular signalling.
1:599-605.
1989
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Norepinephrine and potassium induced calcium translocation in rat vas deferens.
The Journal of pharmacology and experimental therapeutics.
246:917-923.
1988
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Pharmacological classification of receptors for adenyl purines in guinea pig myometrium.
The Journal of pharmacology and experimental therapeutics.
247:1059-1063.
1988
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Increased myocardial beta-receptors and adrenergic responses in hyperthyroid pigs.
The American journal of physiology.
252:H283-H290.
1987
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Alpha-adrenergic receptors on rat ventricular myocytes: characteristics and linkage to cAMP metabolism.
The American journal of physiology.
251:H307-H313.
1986
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Compartmentation of hormone action in adult mammalian cardiomyocytes.
Advances in experimental medicine and biology.
194:117-127.
1986
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Regulation of cAMP metabolism in adult ventricular myocytes: effects of histamine.
Proceedings of the Western Pharmacology Society.
29:55-58.
1986
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Action of the cardiac alpha 1-adrenergic receptor. Activation of cyclic AMP degradation.
1985
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Alpha 1-adrenergic and muscarinic cholinergic stimulation of phosphoinositide hydrolysis in adult rat cardiomyocytes.
Circulation research.
57:532-537.
1985
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Beta-adrenergic receptor subtypes and subcellular compartmentation of cyclic AMP and cyclic AMP-dependent protein kinase in rabbit cardiomyocytes.
Biochemistry international.
11:137-144.
1985
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Direct analysis of beta-adrenergic receptor subtypes on intact adult ventricular myocytes of the rat.
Circulation research.
56:126-132.
1985
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Effect of phosphate depletion on blood pressure and vascular reactivity to norepinephrine and angiotensin II in the rat.
The American journal of physiology.
248:F93-F99.
1985
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Enhancement of adenylate cyclase activity in S49 lymphoma cells by phorbol esters. Putative effect of C kinase on alpha s-GTP-catalytic subunit interaction.
1985
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A kinetic isotope dilution assay for glycerol.
Analytical biochemistry.
139:305-308.
1984
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Compartments of cyclic AMP and protein kinase in mammalian cardiomyocytes.
1983
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The purification of cholinesterase from horse serum.
The Biochemical journal.
143:733-744.
1974
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Blockade of extracellular NM23 or its endothelial target slows breast cancer growth and metastasis.
Integrative cancer science and therapeutics.
2:192-200.
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Effects of Na+ on the muscarinic cholinergic receptor of rat ventricular myocytes.
Journal of cardiovascular pharmacology.
7:476-481.
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editorial article